It remains unsettled whether prenatal exposure to perfluoroalkyl substances (PFASs) affects human reproductive health through potential endocrine disruption. Perfluoroalkyl substances (PFASs) cover a group of synthetic chemicals that induce water, oil, and dirt resistance, and these are used in the manufacturing of a variety of everyday consumer products. The substances are highly environmentally persistent and have long half-lives, thus having the disadvantage of accumulating in humans through various exposure routes, including drinking water, diet, dust, and air.
PFASs cross the placental barrier and were recently detected in placental and fetal tissue from legally terminated pregnancies. This has raised concerns about the potential adverse effects of prenatal exposure to PFASs on later health, including reproductive health. These concerns are supported by an emerging number of in vitro and animal studies, proposing mechanisms by which PFASs may interfere with the endocrine system. We aimed to explore the associations between prenatal exposure to several PFASs and various aspects of pubertal development in boys and girls.