Trine Mogensen



The aim of my research is to understand basic mechanisms in innate immunology relevant to infectious diseases and immunodeficiencies in humans. One part of the research is focused on pathogen sensing and innate immune activation during HIV infection, i.e how HIV infection is sensed/recognized by pattern recognition receptors, the outcome of virus-cell interactions on antiviral activities, activation of chronic inflammation, and viral immune evasion strategies. The other part of the research deals with immunodeficiencies in innate immunity with particular focus on herpes encephalitis and other viral CNS infections and in particular the involvement of deficiencies in production of IFNs due to mutations in the TLR3 signaling pathway.

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