Jo Beldring Henningsen
The Scheele Group investigates the hypothesis that BAT is a regulatory organ in adult human metabolism, which communicates with central and peripheral metabolic units by secreted factors known as batokines. The group has a long experience in working with mesenchymal stem cells derived from adipose tissue biopsies which can be differentiated in vitro into mature adipocytes.
The group study cell identity of progenitors from BAT and WAT at single cell level and maps cell type specific secretomes. Current work includes development of 3D co-culture and organ-on-a-chip cell models, also including other cell types such as neurons and pancreatic alpha cells. “Our goal is to identify batokines that can counteract the development of obesity and type 2 diabetes.”