Novo Nordisk Foundation Center for Stem Cell Medicine, reNEW
The Sedzinski group aims to understand the general principles underlying epithelial homeostasis. Particularly, they want to determine both the mechanics and molecular regulation of epithelial cell renewal from stem cells hoping to provide new insights into treatment of epithelial pathologies associated with defective tissue homeostasis, such as asthma, colitis, and most common epithelial tumours, or carcinomas.
Development and homeostasis of epithelial sheets depend upon the regular addition of new cells and removal of old cells. The last decade has seen an explosion of interest in the mechanisms governing the homeostatic extrusion or delamination of cells from epithelia. These studies reveal a complex interplay between molecular signals and cell mechanics, and underscore the importance of epithelial cell shape in epithelial homeostasis.