Section for Biomolecular Sciences Department of Biology Copenhagen Biocenter, University of Copenhagen
Our research activity is primarily centered on intracellular protein folding, stability and degradation via the ubiquitin-proteasome pathway. The ubiquitin-proteasome system is highly conserved and is the major pathway for intracellular proteolysis in all eukaryotic cells. Accordingly, ubiquitin-dependent protein degradation plays a pivotal role in the turnover of key regulatory proteins involved in a series of cellular processes, including cell cycle control, signal transduction, and protein folding. For a number of years a focus area for us has been how, destabilized, abnormal or misfolded proteins are targeted for degradation. To this end, we use yeast and mammalian cells in tissue culture as model systems, combined with a series of genetic, biochemical and molecular cell biological methods, including high throughput technologies such as deep mutational scanning and genome-wide screens.