Department of Biomedical Sciences, Endocrinology and Metabolism, University of Copenhagen
Ghrelin, an orexigenic peptide, is secreted from endocrine cells in the gastric mucosa. Circulating levels rise in the preprandial phase, suggesting an anticipatory or cephalic phase of release, and decline in the postprandial phase, suggesting either the loss of a stimulatory factor or inhibition by factors released when nutrients enter the intestine.
We hypothesize that vagal signals are not required for the (i) preprandial increase or (ii) postprandial suppression of ghrelin levels. We investigate the hypothesis that (iii) glucagon-like peptide-1 might be implicated in the postprandial decline in ghrelin levels.