Our research focus on the mechanism(s) by which physical activity promotes metabolic health. Our studies have focused on the role of the energy sensor AMP activated protein kinase in promoting adaptations to exercise training and to a single bout of exercise. Of particular interest for now more than 20 years have been the interaction at the intracellular level between exercise-induced signaling events and those induced by insulin trying to elucidate the mechanisms by which a single bout of exercise can improve muscle insulin sensitivity.
Our approaches to gain such insights include invasive studies of healthy and diseased subjects in combination with mechanistic studies using animal models - including various transgenic approaches. We seek to adapt state of art technologies in our research - including metabolomics, proteomics and phosphoproteomics analyses. Further, we seek to gain insight at the single muscle fiber level using both biochemistry and imaging techniques. In collaborations with various clinical laboratories and pharma industries we aim to translate our findings into relevance for patients and society.