Our research group studies dynamic and disordered proteins using biophysical and biochemical methods. We are especially interested in intrinsically disordered proteins, that are completely devoid of a fixed three-dimensional structure.
Intrinsically disordered proteins challenge the dominant paradigm in molecular biology – that the structure of a molecule defines its function. Instead, the function is defined by a higher diverse ensemble of conformation. We aim to understand how.
We use synthetic biology to design new intrinsically disordered proteins with two goals in mind: We seek to understand the design principles of intrinsically disordered proteins and to develop new proteins that can be used in biotechnology.