Frizzled signaling and pharmacology and the role of WNT/Frizzled signaling in biology, physiology and disease. Most importantly my research team tries to understand underlying mechanisms of WNT-receptor interaction, relevance of receptor dynamics and receptor complex composition and specification of downstream signaling. The ultimate aim is to use the new knowlegde to find and create Frizzled-targeting drugs to improve future therapies of human disease.
Gunnar Schulte is Professor in receptor pharmacology and research group leader for the section Receptor Biology and Signaling at the Department of Physiology and Pharmacology. He has a background in biochemistry from the Free University in Berlin/Germany and a PhD in molecular pharmacology (supervisor: Bertil B Fredholm) from Karolinska Institutet. As postdoc he trained first with Ernest Arenas (Karolinska Institutet, Molecular Neurobiology) and later with Roger J Summers (Monash University, Melbourna Australia, GPCR pharmacology) before starting his independent research team "Receptor Biology & Signalling". Gunnar Schulte is also the scientific secretary of the Swedish Society for Medical Research (SSMF) and member on the editorial board/editorial advisory board of Molecular Pharmacology, British Journal of Pharmacology, Pharmacological Reviews, and The Journal of Biological Chemistry.