Danish Research Centre for Magnetic Resonance, Amager and Hvidovre Hospital, Copenhagen
In my work, I use a combination of multi-modal data assessment and computational modeling to deepen our understanding of the human brain in health and disease. Using computational models of learning and decision-making to probe disease-induced changes in brain and behavior allows me to move from descriptive to mechanistic levels of understanding. Working with a multi-modal assessment approach I try to bridge between information about brain structure, brain function, autonomic nervous system function, all the way to symptom assessments to gain novel comprehensive insights into the dopaminergic and noradrenergic system in health and disease. The ultra-high field (7 tesla) MR scanner allows me to map the structural integrity of midbrain nuclei at highest resolution. This allows me to investigate the relationship between the individual spatial pattern of neurodegeneration in Parkinson’s disease and the patient’s clinical symptoms.