Scientific Director, Dr.
Wellcome-MRC Institute of Metabolic Science Metabolic Research Laboratories
My main research involves developing cutting-edge analytical methods to measure specific metabolites and nutrients, and using these methods to facilitate the further understanding of our metabolism and of the role of metabolism in disease. The current technical challenge is to comprehensively analyse all metabolites and lipids (aka metabolomics and lipidomics), which demands developments in experimental design, sample preparation, analysis, data processing and bioinformatics. I have been responsible for the development and application of novel analytical pipelines. These methods enables us to measure metabolites (fatty acids, lipids, etc.) in very large population studies, some of which are still the largest in the world, as well as to measure lipids in single cells (single cell lipidomics). We are currently using these results to understand how genetics and diet are associated with disease risk through metabolism.