Sarvesh Kumar Srivastava
Department of Health Technology, Technical University of Denmark
Drug delivery and Sensing
In the IDUN section, we are working on micro- and nano sensor development and microdevices for drug delivery.
The sensor projects are focusing on micro- and nanosensors as resonating strings, surface enhanced Raman scattering, electrochemistry on a disc and Raman spectroscopy. With these we can for example measure resonance frequency shifts of nanograms of material, perform rapid diagnostics and studies of molecular action of drugs and obtain finger-print spectra to identify unknown compounds.
Furthermore, we are focusing on micrometer sized containers as an oral drug delivery system. The microcontainers are fabricated in polymeric material. Following the fabrication, the microcontainers are loaded with drug using methods such as embossing, inkjet printing and supercritical impregnation. The drug-loaded microcontainers are then coated with a polymeric lid, and the microcontainers are tested in vitro and in vivo for oral drug delivery of for example insulin, antibiotics and vaccines.