Mads Fuglsang Kjølby
Steno Diabetes Center Aarhus and the Department of Clinical Pharmacology at Aarhus University Hospital
Research activities are focused towards the functional characterization of a group of type-1 receptors denoted the Vps10p-domain family, or so-called sortlins, that comprises sortilin, SorLA, and SorCS-1, -2, and -3. The receptors are enriched in neurons where they mediate trafficking and signaling of a vast number of ligands such as neurotrophic factors along with their cognate receptors, neurotransmitter receptors, APP, and progranulin. Among many activities, the receptors regulate neuronal cell fate, differentiation, innervation, synaptic plasticity, and learning and memory. Key goals of the Nykjaer lab is to understand their functions in the heathy brain, dissect out their mode of actions, investigate how genetic variation contributes to disease development - in particular of neuropsychiatric disorders and memory impairment -, and to evaluate their potential as drug targets.