Department of Biology, University of Copenhagen
The aim of our research is to understand RNA based mechanisms involved in the control of cellular processes, in particular those that are related to disease and affects the efficiency of cell based production systems. Moreover, we want to contribute to the further development of RNA based therapies that utilize our knowledge of RNA based mechanisms.
Over the last years, our group has contributed to the further development of methods for detection of RNA modifications and for probing RNA structure. Historically, these methods have been restricted to the analysis of one RNA molecule at the time, but by adapting the experiments for modern sequencing technology and developing novel computational tools, we have increased the throughput of such experiments by several orders of magnitude to make transcriptome wide analysis possible. Our methods give us a unique possibility to identify RNA structural and regulatory changes inside cells.