Finsen Laboratory, Center for Cancer and Organ Diseases, Rigshospitalet and University of Copenhagen
Several cancers, including acute myeloid leukemias (AML), are maintained by cancer stem cells (CSCs). Similar to normal stem cells, CSCs are able to self-renew and are thus the cells that need to be targeted in order to efficiently eradicate the disease. The focus of the Porse group is therefore to study cancer from a stem-cell centric viewpoint. Specifically, we address the molecular mechanisms governing both normal and malignant hematopoiesis with the aim to identify novel targets for future therapeutic intervention in patients suffering from AML.