S M Nazmus Salehin
Postdoc
Novo Nordisk Foundation Center for Stem Cell Medicine, reNEW, University of Copenhagen, Denmark
Biography
The Brickman Group aims to understand mechanism(s) governing cellular decision-making, competence and plasticity during development and differentiation. We seek to exploit the transcriptional underpinnings of cell states to develop new stem cell models at the same time as using these models to probe molecular mechanisms of enhancer activity and how enhancers interpret signaling at the level of transcription.
We focus on how transcription is regulated, how it integrates signaling response and how transcription factor behavior explains stem cell plasticity, potency, and differentiation. These fundamental studies into molecular mechanism have already led to innovations that include the first human hypoblast stem cells, drugs for improved liver and pancreas differentiation and new approaches to IVF culture.
