Department of Medicine at Leiden University Medical Center in the Netherland
Obesity is a major risk factor for the development of cardiovascular diseases which are considered the leading cause of death worldwide. The transport of lipids in the blood via lipoproteins is crucial for the regulation of whole-body lipid metabolism.
Hence, targeting elevated plasma low density lipoprotein (LDL)-cholesterol and triglycerides that are directly linked to the development of atherosclerosis is the primary treatment goal. Apart from pharmaceutical interventions, exercise is known to modulate plasma triglycerides and improve cardiometabolic health, yet the molecular connection between exercise, the transport of lipids in the blood and atherosclerosis development is not fully understood.
The regulation of metabolic processes is adjusted to the change of day and night by central and peripheral clocks. It is, however, not known whether the effect of exercise on the regulation of metabolism and atherosclerosis development varies depending on the time of exercise.