CARD Deputy Director and Professor
Our Lab is committed to unravelling the upstream regulation of autophagy and elucidating the role of this process in cancer. In cancer, autophagy may serve as a barrier to limit tumour initiation and as an adaptive response functional to malignant progression in the established neoplastic lesions. In addition to ties to the tumorigenesis, there is also evidence for a direct role for autophagy in controlling cell proliferation and vice versa, but less is known about this relationship. In this context, in our lab we are studying the function of the pro-autophagic protein AMBRA1 in cell cycle regulation and its implications in tumour insurgence.