Ana Martínez del Val
The group has a long-standing interest in applying their proteomics technology developments to systems-wide analyses of dynamic post-translational modifications such as site-specific phosphorylation that regulate essentially all cellular signal transduction pathways.
“We are interested in understanding how different growth factors binding to the same receptor on the outside of cells activate differential signaling pathways and signals different cellular outcomes – a phenomenon known as functional selectivity. Developing and applying quantitative mass spectrometry-based proteomics technologies allows us to generate quantitative maps of modifications, interactome and protein expression changes as a function of stimuli and stimulation time. These datasets form the basis of hypothesis generation that we test using different cell-based assays,” says Professor and Group Leader Jesper Olsen.