Iris Bea Ramiro
Postdoctoral fellow
Department of Biomedical Sciences, Molecular Cardiology and Membrane Proteins, the University of Copenhagen
Biografi
We study proteins in health and disease with focus on cardiac and neurological disorders. Our methods range from studies in cell-free systems, molecular and cellular assays, ex vivo techniques (e.g. perfused hearts), in vivo techniques and state-of-the-art structural biology. We employ small and large animal models, ranging from zebrafish to pigs. We have frontline expertise within X-ray crystallography and cryoEM, imaging, genomics, transcriptomics, proteomics, and access to a variety of well-defined human cohorts.
We study structure-function-disease relationships of a broad range of membrane proteins involved in cell homeostasis and transport across cell membranes. We focus on the roles and mechanisms of ion channel complexes, transport proteins and receptors. We address the impact of mutations, molecular regulatory mechanisms and accessory subunits. We characterize the physiology and dynamics of ion channel subunits in the heart, in neurons and epithelia.
